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Current Pharmaceutical Analysis
ISSN (Print): 1573-4129
ISSN (Online): 1875-676X
VOLUME: 10
ISSUE: 1
DOI: 10.2174/157341291001140102110607









Fast and Efficient Monitoring of Diclofenac Dissolution Profile by CE

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Author(s): Celina M. Monzon, Luciana Vera-Candioti, María del C. Sarno and Mario R. Delfino (h)
Pages 38-43 (6)
Abstract:
Capillary electrophoresis (CE) was used to follow Diclofenac tablet dissolution, in very short times and allowing dissolution testing without volume replacement. By using Student´s t test and F-test, this CE method was compared with HPLC. Statistical data show that there are no significant differences among them. The drug release kinetic of diclofenac tablets was described by various mathematical models and equations. Model-Independent Methods: t50% = 10.34 min; t80% = 20 min; DE% = 79.41% and MDT = 10.85 min, show that diclofenac tablet dissolution rate is very high, having 80% drug dissolution within 20 minutes. Model-Dependent Methods. The kinetics models used were: zero order, first order, Hixson–Crowell cube root law, Higuchi model, and Weibull model. Criteria used to choose the best model was by comparisson of r2 and AIC (Akaike Information Criteria). The model that best adjusts diclofenac tablet dissolution profile was the Hixson-Crowell cube root model.
Keywords:
Capillary electrophoresis, diclofenac, dissolution, Hixson-Crowell, quantification, tablets.
Affiliation:
School of Exact and Natural Sciences - Northeastern National University (UNNE), Instrumental Analysis Laboratory- Av. Libertad 5640- Corrientes- Argentina.