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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 14
ISSUE: 2
DOI: 10.2174/1389557513666140103102447      Price:  $58









Development of Thiadiazole as an Antidiabetic Agent- A Review

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Author(s): Prasanna A. Datar and Tejashree A. Deokule
Pages 136-153 (18)
Abstract:
This review provides a brief summary of thiadiazole ring containing compounds as antidiabetic agents. It covers the most active thiadiazole derivatives selected from reported literature of thiadiazole system as antidiabetic drug substance in the form of synthesis and structural activity relationship study reports. Some of the promising thiadiazole compounds interacting with targets such as sodium-glucose linked transporter, peroxisome proliferator-activated receptor, protein tyrosine phosphatase, c-Jun N-terminal kinase, dipeptidyl peptidase-4 and cannabinoid-1 receptor have been collected with their biological potency. The information provided in this review acts as important overview for medicinal chemist to develop a new chemical entity possessing antidiabetic activity.
Keywords:
Antidiabetic, cannabinoid-1 receptor, c-Jun N-terminal kinase, dipeptidyl peptidase-4, peroxisome proliferatoractivated receptor, protein tyrosine phosphatase, sodium-glucose linked transporter, thiadiazole.
Affiliation:
Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune-400041, India.