Recent Patents in Cartilage Regeneration
Luminita Labusca, Udo Greiser, Viorel Nacu, Florin Zugun-Eloae and Kaveh Mashayekhi
Pages 52-68 (17)
The limited capability of articular cartilage to heal after injury and the worldwide increase in the burden of
diseases related to osteoarthritis, are prompting numerous efforts in developing novel treatments. Methods of grafting,
promoting tissue repair or regenerative medicine strategies are in different stages of investigation. However, in the last
decades, inadequate few novel therapies have made their way to the clinic gaining limited acceptance. Some of the
reasons of the relative lack of progress are the insufficient quality and stability of the repair tissue and the lack of serious
evidence based medicine information to support the use and reimbursement of new procedures. This paper introduces the
most recent patents which relate to cartilage regeneration. Grafting procedures and their conceptual development, regenerative
medicine strategies as well as drug, physical and food supplements based methods are listed. Main issues encountered
with every intervention type and the way new methods are addressing them, are also discussed.
Cartilage, defects, osteoarthritis, patents, regeneration, therapy.
Department of Orthopedic Surgery, University Hospital, Saint Spiridon Iasi, 1st Independentei Boulevard Iasi, Romania.