Login

Journal Image
Current Topics in Medicinal Chemistry
ISSN (Print): 1568-0266
ISSN (Online): 1873-5294
VOLUME: 14
ISSUE: 5
DOI: 10.2174/1568026614666140118204000      Price:  $58









Assembled Core-Shell Nanostructures of Gold Nanoparticles with Biocompatible Polymers Toward Biology

img
Author(s): Dongxiang Li, Qianru Li, Xiongwen Hao, Yaojun Zhang, Zhupeng Zhang and Chunfang Li
Pages 595-616 (22)
Abstract:
The present review focuses on core-shell nanostructures of spherical gold nanoparticles (Au NPs) and biocompatible polymers mainly from the view points of preparation approaches, nanocomposite properties and potential applications for biology. The preparation approaches are assorted into direct-reduction, covalent “graft-to”, “graft-from” approach, surface bonding and physical adsorption. Various biocompatible polymers are involved such as the thermosensitive polymers, pH-responsive polymers, antibiofouling polymers, conductive polymers and several natural polymers. The encapsulating and loading properties, cellular uptake and drug release control, as well as biorecognition, targeting and sensing potential are discussed in connection with biological systems. These polymeric gold nanocomposites will have a great potential in biotechnology and life science but also face enormous challenge in future applications.
Keywords:
Nanostructures, gold nanoparticles, biopolymers, core-shell, biology.
Affiliation:
State Key Laboratory Base of Eco-chemical Engineering, Lab of Colloids and Functional Nanostructures, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.