Diabetes is a chronic metabolic disorder in humans constituting a major health concern today whose prevalence
has continuously increased worldwide over the past few decades. Production of reactive oxygen species (ROS) and disturbed
capacity of antioxidant defense in diabetic subjects have been reported. It has been suggested that enhanced production
of free radicals and oxidative stress is the central event for the development of diabetic complications. Antioxidants
can play an important role in the improvement of diabetes. There are many reports on the effects of antioxidants in
the management of diabetes. This study aimed at evaluating the effect of antioxidant extract and purified sweet and sour
Cherries on hyperglycemia, microalbumin and creatinine level in alloxan-induced diabetic rats. Thirty six adult Male Wistar
rats were divided equally into six groups. Diabetes was induced in the rats by an intraperitoneal injection with 120
mg/kg body weight of alloxan. Oral administration of cherry extract at a concentration of 200 mg/kg body weight for 30
days significantly reduced the levels of blood glucose, and urinary microalbumin. Also an increase in the creatinine secretion
level in urine was observed in the diabetic rats treated with the cherry extract as compared to untreated diabetic rats.
In this paper, the most recent patent on the identification and treatment of diabetes is used. In conclusion, cherry antioxidant
extract proved to have a beneficial effect on the diabetic rats in this study. In light of these advantageous results, it is
advisable to broaden the scale of use of sweet and sour cherries extract in a trial to alleviate the adverse effects of diabetes.
Alloxan, antioxidant, blood glucose, cherry, diabetes, diabetic rat.
Department of Biology, Faculty of Science, PNU University, Hamedan, Iran.