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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 14
ISSUE: 2
DOI: 10.2174/1389557514666140123144942      Price:  $58









Tetraoxanes as Antimalarials: Harnessing the Endoperoxide

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Author(s): Laura C. Fisher and Margaret A.L. Blackie
Pages 123-135 (13)
Abstract:
With the emergence of resistance to artemesinin, the need for new antimalarial compounds is pressing. Several research groups have made significant contributions to the exploration of the use of 1,2,4,5-tetraoxanes and 1,2,4- trioxanes as synthetic analogues of artemesinin. This short review highlights the recent developments in this field detailing both biological results and useful synthetic methodology. In addition, the current understanding of the mode of action of this class of compounds has been described.
Keywords:
Endoperoxide, malaria, plasmodium falciparum, tetraoxane.
Affiliation:
Stellenbosch University, Department of Chemistry and Polymer Science, Private Bag X1, Matieland, 7602, Stellenbosch, South Africa