A major concern in base catalyzed Henry reaction for the synthesis of β-nitroalcohol from the reaction of aldehyde
and nitroalkane is instantaneous formation of nitroalkene by dehydration, which in turn facilitates many side reactions.
It is observed that rapid synthesis of β-nitroalcohol can be accomplished by carrying out the reaction in aqueous
phosphate buffer at pH 7.0 under microwave irradiation without using any additional base. Use of microwave irradiation
facilitated the formation of β-nitroalcohol within a very short time, yet no instantaneous formation of nitroalkene was observed
even at 80 °C.
Aldehyde, base-free, henry reaction, high temperature, microwave irradiation, β-nitroalcohol, nitroalkane, no side
reaction, no diastereoselecivity, phosphate buffer, pH 7.0.
Department of Chemistry, North Eastern Hill University, Shillong-793022, India.