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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)
ISSN (Print): 1871-5230
ISSN (Online): 1875-614X
VOLUME: 13
ISSUE: 1
DOI: 10.2174/1871523013999140130121134









Zinc-Aceclofenac Complex: Synthesis, Hydrolysis Study and Antiinflammatory Studies

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Author(s): Mayura A. Kale, Rupesh Shelke and Rajesh B. Nawale
Pages 36-44 (9)
Abstract:
Aceclofenac, a nonsteroidal anti-inflammatory drug, has a propensity to cause gastric ulcers, while zinc ions are known to possess anti-ulcer and anti-inflammatory activities. With a view to reduce the gastroenteropathies associated with aceclofenac, its zinc complex was prepared and characterized using spectroscopy and differential scanning calorimetry. In vitro hydrolysis study showed that zinc complex of aceclofenac is more stable in HCl buffer (pH 1.2) than in phosphate buffer (pH 7.4) indicating the stability of the complex in stomach. In silico testing of the aceclofenac and its complex using PASS (Prediction of activity spectra of substances) software revealed that the complex might possess antiinflammatory activity which was confirmed by carrageenan-induced rat paw edema test. It has been found that antiinflammatory activity of this complex is comparable with that of parent drug along with reduction in ulcer index. Thus, the use of complex is suggested to be more preferable than aceclofenac alone.
Keywords:
Anti-inflammatory, anti-ulcer & PASS, ulcer index, zinc-aceclofenac complex.
Affiliation:
Government College of Pharmacy, opposite Government Polytechnic, Railway station road, Osmanpura, Aurangabad (M.S) 431-005, India.