Abstract
A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.
Keywords: Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.
Letters in Drug Design & Discovery
Title:Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents
Volume: 11 Issue: 6
Author(s): Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song and Na Li
Affiliation:
Keywords: Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.
Abstract: A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.
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Cite this article as:
Jiang Yi, Xu Hong, Liu Li, He Rui, Song Xiaomei and Li Na, Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents, Letters in Drug Design & Discovery 2014; 11 (6) . https://dx.doi.org/10.2174/1570180811666140130232233
DOI https://dx.doi.org/10.2174/1570180811666140130232233 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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