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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 11
ISSUE: 6
DOI: 10.2174/1570180811666140130232233      Price:  $58









Synthesis and Anti-Cancer Activities of Aryl Benzyl Ethers with Fluoro Substituents

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Author(s): Yi Jiang, Hong Xu, Li Liu, Rui He, Xiaomei Song and Na Li
Pages 736-741 (6)
Abstract:
A series of aryl benzyl ethers with fluoro substituents were synthesized and their structures were confirmed by spectral. All the compounds were tested for their cytotoxic activity in vitro against two human tumor cell lines: A549, SGC7901, and most showed cytotoxicity. Compound 10 was the most active in suppressing the growth of both screened cancer cells.
Graphical Abstract:
Keywords:
Cancer, Drug design, Anti-cancer activity, Aryl benzyl ethers, Fluoro substituents, Structure-activity relationship.
Affiliation:
Shaanxi university of Chinese medicine, shijidadao, xianyang, 712046, China.