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Recent Patents on CNS Drug Discovery
ISSN (Print): 1574-8898
ISSN (Online): 2212-3954
DOI: 10.2174/2212798406666140131122641

Recent Advances in the Treatment of Neurogenic Erectile Dysfunction

Author(s): Rocco S. Calabro, Giovanni Polimeni and Placido Bramanti
Pages 41-53 (13)
Neurogenic erectile dysfunction (ED) can be broadly defined as an inability to sustain or maintain a penile erection owing to a neurological impairment, either centrally or peripherally or both. Although significant advances in the pharmacological treatment of ED have occurred in recent years, especially after the introduction of oral selective phosphodiesterase type 5 inhibitor, the treatment of neurological patients with ED may be challenging for prescribers, given poor data available on this topic and the variety of etiologic factors (iatrogenic, endocrine, psychiatric and psychosocial) to consider. At the same time, several, new oral, local and surgical treatments are available and their efficacy and safety depend on the specific cases. This review provides a comprehensive and updated description of current and future ED therapies, including assigned patents, with a special focus on the treatment of neurogenic erectile dysfunction.
Dopaminergic agonists, guanylate-cyclase activators, melanocortins, neurogenic erectile dysfunction, patents, PDEi, potassium channel inhibitors.
Neurorehabilitation Unit, IRCCS Centro Neurolesi “Bonino Pulejo” , via Palermo, S.S. 113, C.da Casazza, 98124 Messina, Italy.