Coronary artery spasm is one of the causes of angina pectoris,acute myocardial infarction and ventricular
fibrillation-related sudden death. It has been established that Ca channel blockers are protective against vasospastic angina
(VSA) and treatment with Ca channel blockers provides a better prognosis of VSA. However, it is not still clarified what
kinds of Ca channel blockers shows the best prognosis of VSA. We performed a meta-analysis in which 4Ca channel
blockers amlodipine, nifedipine, benidipine and diltiazem were used for the treatment of VSA patients and found that
among 4 Ca channel blockers, benidipine showed a statistically significant better prognostic effect on MACE than
amlodipine, nifedipine or diltiazem.
Ca channel blocker, cardiovascular event, vasospastic angina.
Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1-1, Gifu, Gifu 501-1194, Japan.