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Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)
ISSN (Print): 1871-5206
ISSN (Online): 1875-5992
VOLUME: 14
ISSUE: 3
DOI: 10.2174/187152061403140207163402      Price:  $58









Microtubule-targeting Anticancer Agents from Marine Natural Substance

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Author(s): Zhiguo Liu, Pengfei Xu, Tao Wu and Wenbin Zeng
Pages 409-417 (9)
Abstract:
Effective novel therapeutics is urgently needed due to increasing incidence of malignant cancer and drug multi-resistance. Natural products and their derivatives have historically been a source of pharmaceutical leads and therapeutic drugs. Microtubuletargeting compounds are among the most promising candidates in the combat against cancer. In particular, marine natural products (MNPs) have demonstrated exceptional potency and potential as anticancer agents. Drug discovery from MNPs provides a new pathway to develop original anticancer agents. In this review, seven classes of typical MNPs with diverse structures are summarized. Bioactive marine compounds isolated from different organisms including invertebrate animals, algae, fungi and bacteria are also discussed.
Keywords:
Anticancer, marine, microtubule, natural products.
Affiliation:
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China