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Letters in Organic Chemistry
ISSN (Print): 1570-1786
ISSN (Online): 1875-6255
VOLUME: 11
ISSUE: 7
DOI: 10.2174/1570178611666140210213413      Price:  $58









Catalyst Free One-pot Three-component Synthesis of 2-Amino-4Hchromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature

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Author(s): Atul Chaskar
Pages 480-486 (7)
Abstract:
Multifunctional chromenes have been efficiently synthesized in aqueous medium at room temperature using deep eutectic mixture of choline chloride:urea. In this one-pot synthesis, the benzylidenemalononitrile firstly formed by Knoevenagel condensation of aldehyde and malononitrile eventually underwent Michael addition-cyclization with dimedone and offered the chromenes in good to excellent yield.
Graphical Abstract:
Keywords:
5-exo-Cyclisation, 6-endo Cyclization, AIBN, Pyrimidine, Radical reaction, Sulfur heterocycles, Tributyltin hydride.
Affiliation:
Department of Dyestuff Technology, Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai - 400 019, India.