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Current Stem Cell Research & Therapy
ISSN (Print): 1574-888X
ISSN (Online): 2212-3946
VOLUME: 9
ISSUE: 3
DOI: 10.2174/1574888X09666140213155800









Potential Replication of Induced Pluripotent Stem Cells for Craniofacial Reconstruction

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Author(s): Yao Fu, Shuwen Deng, Jing Wang, Zhaozhao Chen, Shu Zhang, Songtao Wu, Yan Jiang, Ling Ye, Qiang Peng and Yunfeng Lin
Pages 205-214 (10)
Abstract:
The craniofacial region contains many specified tissues, including bone, cartilage, muscle, blood vessels, fat, skin and neurons. A defect or dysfunction of the craniofacial tissue after post-cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient’s life. Therefore, functional reconstruction of damaged tissues is highly sought. The use of cell-based therapies represents one of the most advanced methods for enhancing the regenerative response for craniofacial wound-healing. The recently acquired ability to reprogram human adult somatic cells to induced pluripotent stem cells (iPSCs) in culture may provide a powerful tool for in vitro disease modeling and an unlimited source for cell replacement therapy. This review focuses on the generation, biological characterization and discussion of the potential application of iPSCs for craniofacial tissue-engineering applications.
Keywords:
Cell differentiation, craniofacial reconstruction, embryonic stem cells, induced pluripotent stem cells, regenerative medicine, somatic cells.
Affiliation:
State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No.14., 3rd Sec, Ren Min Nan Road, Chengdu, 610041. P.R. China.