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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 11
ISSUE: 6
DOI: 10.2174/1570180811666140214204858      Price:  $58









A Potential Anticancer Agent 1,2-di(quinazolin-4-yl)diselane

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Author(s): Yinjiu Huang, Gang Liu, Xiaomei Hu, Hao Liu, Jianguo Hu, Zhenzhong Feng, Bi Tang, Jun Qian, Qiyi Wang and Xuehui Long
Pages 731-735 (5)
Abstract:
The development of antitumor drugs with novel effects is urgent for cancer patients. In our recent anticancer drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) was synthesized and showed considerable antitumor effects on six tested cancer cell lines in vitro. Morphological observation and Lactate Dehydrogenase release assay revealed that LG003 exerted such effect in A549 cells through antiproliferation, apoptosis or other pathway rather than cytotoxicity which suggests that compound LG003 is a potential antitumor agent.
Graphical Abstract:
Keywords:
1, 2-di(quinazolin-4-yl)diselane, Anticancer activity, Cytotoxicity, A549, Anticancer agent, Breast cancer.
Affiliation:
School of Chemistry and Materials Science, Ludong University, Yantai 264025, PR China.