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Current Cardiology Reviews
ISSN (Print): 1573-403X
ISSN (Online): 1875-6557
DOI: 10.2174/1573403X10999140226121300

Wave Intensity Analysis in the Human Coronary Circulation in Health and Disease

Author(s): Sayan Sen, Ricardo Petraco, Jamil Mayet and Justin Davies
Pages 17-23 (7)
Coronary artery hemodynamics are very different to that of the systemic arteries; unlike the systemic circulation, in the coronary circulation pressure is generated from both the proximal and distal end of the artery – due to the effect of contraction and relaxation of the myocardium on the microvasculature. As a result, the systemic artery hemodynamic model cannot be used to explain the pressure-flow relationship in the coronaries. Wave intensity analysis is an investigative tool that is able to distinguish simultaneous proximal and distal influences on coronary blood flow and is therefore uniquely suitable for the study of coronary haemodynamics. This review discusses the concept behind waveintensity analysis and evaluates how it has been used to characterise and provide new insights on coronary haemodynamics in health and disease.
Collaterals, iFR, wave intensity.
International Centre of Circulatory Health, National Heart and Lung Institute, 59-61 North Wharf Road, London, W2 1LA, UK.