Abstract
For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are generated and function will help with diagnostic tools and therapeutic strategies. This review encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs.
Keywords: miRNA biogenesis, canonical pathways, non-canonical pathways, circulating miRNAs.
Current Gene Therapy
Title:MicroRNA Pathways: An Emerging Role in Identification of Therapeutic Strategies
Volume: 14 Issue: 2
Author(s): Soundararajan Vijayarathna, Chern E. Oon, Subramanion L. Jothy, Yeng Chen, Jagat R. Kanwar and Sreenivasan Sasidharan
Affiliation:
Keywords: miRNA biogenesis, canonical pathways, non-canonical pathways, circulating miRNAs.
Abstract: For years researchers have exerted every effort to improve the influential roles of microRNA (miRNA) in regulating genes that direct mammalian cell development and function. In spite of numerous advancements, many facets of miRNA generation remain unresolved due to the perplexing regulatory networks. The biogenesis of miRNA, eminently endures as a mystery as no universal pathway defines or explicates the variegation in the rise of miRNAs. Early evidence in biogenesis ignited specific steps of being omitted or replaced that eventuate in the individual miRNAs of different mechanisms. Understanding the basic foundation concerning how miRNAs are generated and function will help with diagnostic tools and therapeutic strategies. This review encompasses the canonical and the non-canonical pathways involved in miRNA biogenesis, while elucidating how miRNAs regulate genes at the nuclear level and also the mechanism that lies behind circulating miRNAs.
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Vijayarathna Soundararajan, Oon E. Chern, Jothy L. Subramanion, Chen Yeng, Kanwar R. Jagat and Sasidharan Sreenivasan, MicroRNA Pathways: An Emerging Role in Identification of Therapeutic Strategies, Current Gene Therapy 2014; 14 (2) . https://dx.doi.org/10.2174/1566523214666140302192953
DOI https://dx.doi.org/10.2174/1566523214666140302192953 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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