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Current Nutrition & Food Science
ISSN (Print): 1573-4013
ISSN (Online): 2212-3881
DOI: 10.2174/1573401310666140306005334      Price:  $58

The J-shaped Association Between Alcohol Consumption and Breast Cancer: A Case-Control Study

Author(s): Niki Mourouti, Meropi D. Kontogianni, Christos Papavagelis, Theodora Psaltopoulou, Petrini Plytzanopoulou, Tonia Vassilakou, Nikolaos Malamos, Athena Linos and Demosthenes B. Panagiotakos
Pages 120-127 (8)
Background: Alcohol is considered to be a co-carcinogen as well as a tumor promoter, with several studies showing a linear dose-dependent association. However, moderate alcohol consumption has been found to be protective as far as cardiovascular diseases are concerned.

Objective: The aim of this study was to evaluate the association of alcohol intake with breast cancer.

Design: It is a case – control study.

Patients: Two hundred and fifty consecutive newly (within six months) diagnosed breast cancer patients with first developed breast cancer (56±12 years) and 250 age-matched controls were studied.

Main Outcome Measures: A special questionnaire assessing various socio-demographic, clinical, lifestyle and dietary characteristics, was applied through face-to-face interviews. Moreover, frequency of alcohol intake (i.e., never, rarely, 3-4 times/month, 1-2 times/week, 3-4 times/week, daily) and type (i.e., red or white wine, beer, whisky, other beverages) of alcoholic beverages consumed were also recorded. Adherence to the Mediterranean diet was evaluated using the MedDietScore (theoretical range 0-55).

Results: Alcohol drinking on a weekly basis (i.e., 3-4 times/week) was associated with lower likelihood of having breast cancer (OR=0.16; 95%CI 0.03, 0.80), while higher consumption showed opposite results. Moreover, it was revealed that wine drinking was associated with lower odds of breast cancer (OR=0.60; 95%CI 0.35, 1.00) with no significant differences between red or white wine.

Limitations: The major limitation of this study was the potential recall bias.

Conclusions: Moderate alcohol intake, and especially wine consumption, seem to be associated with breast cancer prevention.

Diet, alcohol, breast cancer, nutrition.
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.