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Current Bioactive Compounds
ISSN (Print): 1573-4072
ISSN (Online): 1875-6646
VOLUME: 9
ISSUE: 4
DOI: 10.2174/1573407210666140307011414      Price:  $58









Synthesis and Pharmacological Screening of Novel 1,3-Disubstituted 5-Pyrazolones as Anticonvulsant Agents

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Author(s): Basant Kumar Singh, Narsingh Sachan and Pooja Chawla
Pages 279-287 (9)
Abstract:
Two series of novel 1-(4-substitutedbenzoyl)-3-((2-oxoimidazolin-1-yl)methyl)-1H-pyrazol-5(4H)-one, 1- methyl-3-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)methyl)urea,1-((1-(4-substitutedbenzoyl)-5-oxo- 4,5-dihydro-1H-pyrazol-3-yl)methyl) thio urea and 1-((1-(4-substitutedbenzoyl)-5-oxo-4,5-dihydro-1H-pyrazol-3- yl)methyl)-3-phenyl thiourea were synthesized and characterized by IR, mass, 1HNMR spectroscopic techniques. The synthesized compounds were evaluated for anticonvulsant activity by using maximal electroshock seizure (MES) model. Among the newly synthesized compounds, most of the compounds showed significant activity and 1C2 emerged as the most active analogue.
Keywords:
Anticonvulsant, convulsion, MES, pharmacophore, pyrazol-5-one.
Affiliation:
Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Lucknow- 226028, India.