Abstract
This study describes the synthesis of four 2,4,5-triarylimidazole derivatives and their anticancer activities. The target compounds were prepared from the reaction of benzaldehyde and benzoin derivatives in presence of ammonium acetate and ammonium vanadate. All the synthesized compounds were screened for anticancer activities against T47D and MDA-MB231 cell lines using the MTT assay. However, our obtained results indicated a significant difference between colchicines cytotoxicity and their homologs on treated MDA-MB231 and T47D cells; one compound (4a) showed a significant IC50 on MDA-MB231 cells in cell culture assay.
Keywords: 2, 4, 5-triarylimidazole, Synthesis, Anticancer, Cytotoxicity, T47D, MDA-MB231.
Letters in Drug Design & Discovery
Title:Synthesis and Anticancer Activity of 2,4,5-triaryl Imidazole Derivatives
Volume: 11 Issue: 7
Author(s): Fatemeh Elahian, Morteza Akbari, Maryam Ghasemi, Neda Behtooee, Mohaddeseh Taheri and Mohsen Amini
Affiliation:
Keywords: 2, 4, 5-triarylimidazole, Synthesis, Anticancer, Cytotoxicity, T47D, MDA-MB231.
Abstract: This study describes the synthesis of four 2,4,5-triarylimidazole derivatives and their anticancer activities. The target compounds were prepared from the reaction of benzaldehyde and benzoin derivatives in presence of ammonium acetate and ammonium vanadate. All the synthesized compounds were screened for anticancer activities against T47D and MDA-MB231 cell lines using the MTT assay. However, our obtained results indicated a significant difference between colchicines cytotoxicity and their homologs on treated MDA-MB231 and T47D cells; one compound (4a) showed a significant IC50 on MDA-MB231 cells in cell culture assay.
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Elahian Fatemeh, Akbari Morteza, Ghasemi Maryam, Behtooee Neda, Taheri Mohaddeseh and Amini Mohsen, Synthesis and Anticancer Activity of 2,4,5-triaryl Imidazole Derivatives, Letters in Drug Design & Discovery 2014; 11 (7) . https://dx.doi.org/10.2174/1570180811666140313233659
DOI https://dx.doi.org/10.2174/1570180811666140313233659 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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