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Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
VOLUME: 17
ISSUE: 7
DOI: 10.2174/1386207317666140314092412      Price:  $58









Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents

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Author(s): Afsar Ali Siddiki, Vinod Kumar Bairwa and Vikas N. Telvekar
Pages 630-638 (9)
Abstract:
A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.
Keywords:
Anti-tubercular, benzimidazole, carbohydrazide esters, triclosan, molecular hybridization.
Affiliation:
Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Mumbai 400 019, India.