Abstract
A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.
Keywords: Anti-tubercular, benzimidazole, carbohydrazide esters, triclosan, molecular hybridization.
Combinatorial Chemistry & High Throughput Screening
Title:Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents
Volume: 17 Issue: 7
Author(s): Afsar Ali Siddiki, Vinod Kumar Bairwa and Vikas N. Telvekar
Affiliation:
Keywords: Anti-tubercular, benzimidazole, carbohydrazide esters, triclosan, molecular hybridization.
Abstract: A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.
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Cite this article as:
Siddiki Ali Afsar, Bairwa Kumar Vinod and Telvekar N. Vikas, Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents, Combinatorial Chemistry & High Throughput Screening 2014; 17 (7) . https://dx.doi.org/10.2174/1386207317666140314092412
DOI https://dx.doi.org/10.2174/1386207317666140314092412 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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