The multifunctional nanostructured materials hold the promise for the applications in future clinical treatment
to enhance therapeutic efficacy. In the past several decades, various types of nanostructured materials with multifunctional
properties have been developed and investigated for the biomedical applications. Although many achievements have been
made, the design and preparation of novel multifunctional nanostructured biomaterials with well-defined structures, sizes
and morphologies are still a long-term research direction. Calcium phosphate (CaP) nanostructured biomaterials with high
biocompatibility are the ideal candidates for multifunctional nanosystems, and have been studied and applied in many
biomedical fields such as bone repair/tissue engineering, drug/gene delivery. Compared with pure CaP materials, CaP
based composite nanostructured materials, prepared by adding functional elements, molecules or other materials, have excellent
properties and promising applications in hard tissue engineering, drug delivery, magnetic targeting and
hyperthermia treatment for cancer, antibacterial, bioimaging, and so on. This review article is not intended to offer a comprehensive
review on the research on CaP based multifunctional nanostructured materials and their applications in the
biomedical fields, but shall present a brief summary of the recent progress in this exciting and rapidly evolving research
Bioimaging, calcium phosphate, drug delivery, hydroxyapatite, multifunction, nanostructure, tissue engineering.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P.R. China.