Abstract
The main purpose of this study is to develop a sensitive and selective modified carbon-paste electrode (CPE) with multiwall carbon nanotubes (MWCNTs) for the determination of 6-mercaptopurine (6-MP) in the presence of methyldopa (MD) as a mediator. Electrochemical methods, such as cyclic voltammetry, double step chronoamperometry and square wave voltammetry (SWV), used to study the characterization of the proposed modified electrode. The results show that MD can catalyze the oxidation of 6-MP in aqueous solution. Also, the catalytic rate constant (k), and diffusion coefficient (D) for 6-MP were estimated. The pick currents of 6-MP increased linearly with concentration in the ranges of 0.31–550 µmol L–1, with detection limit of 0.1 µmol L–1. The relative standard deviation (RSD %) for seven replicate measurements of 0.7 µmol L–1 6-MP was 1.6%. The prepared electrode is successfully applied for the voltammetric determination of 6-MP in pharmaceutical and biological samples.
Keywords: 6-Mercaptopurine determination, electrocatalysis, methyldopa, multiwall carbon nanotubes paste electrode, voltammetry.
Current Nanoscience
Title:Electrocatalytic Determination of 6-Mercaptopurine Using Multiwall Carbon Nanotubes Paste Electrode in the Presence of Methyldopa
Volume: 10 Issue: 4
Author(s): Ali Sharifian Isfahani, Mohsen Keyvanfard, Behzad Rezaei and Khadijeh Alizad
Affiliation:
Keywords: 6-Mercaptopurine determination, electrocatalysis, methyldopa, multiwall carbon nanotubes paste electrode, voltammetry.
Abstract: The main purpose of this study is to develop a sensitive and selective modified carbon-paste electrode (CPE) with multiwall carbon nanotubes (MWCNTs) for the determination of 6-mercaptopurine (6-MP) in the presence of methyldopa (MD) as a mediator. Electrochemical methods, such as cyclic voltammetry, double step chronoamperometry and square wave voltammetry (SWV), used to study the characterization of the proposed modified electrode. The results show that MD can catalyze the oxidation of 6-MP in aqueous solution. Also, the catalytic rate constant (k), and diffusion coefficient (D) for 6-MP were estimated. The pick currents of 6-MP increased linearly with concentration in the ranges of 0.31–550 µmol L–1, with detection limit of 0.1 µmol L–1. The relative standard deviation (RSD %) for seven replicate measurements of 0.7 µmol L–1 6-MP was 1.6%. The prepared electrode is successfully applied for the voltammetric determination of 6-MP in pharmaceutical and biological samples.
Export Options
About this article
Cite this article as:
Isfahani Sharifian Ali, Keyvanfard Mohsen, Rezaei Behzad and Alizad Khadijeh, Electrocatalytic Determination of 6-Mercaptopurine Using Multiwall Carbon Nanotubes Paste Electrode in the Presence of Methyldopa, Current Nanoscience 2014; 10 (4) . https://dx.doi.org/10.2174/1573413710666140321235942
DOI https://dx.doi.org/10.2174/1573413710666140321235942 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Aberrant Expression of MicroRNAs in B-cell Lymphomas
MicroRNA Sporadic Porphyria in a Patient with Stage II Melanoma Treated with Interferon α
Current Drug Safety Pharmacogenetics and the Pharmaceutical Industry
Current Pharmaceutical Design Signal Transduction and Photodynamic Therapy
Current Signal Transduction Therapy The Ubiquitin+Proteasome Protein Degradation Pathway as a Therapeutic Strategy in the Treatment of Solid Tumor Malignancies
Anti-Cancer Agents in Medicinal Chemistry An Overview of Synthesis of Indole Alkaloids and Biological Activities of Secondary Metabolites Isolated from Hyrtios Species
Mini-Reviews in Medicinal Chemistry Molecular Foundations for Personalized Therapy in Prostate Cancer
Current Drug Targets Retroviral Gene Therapy: Safety Issues and Possible Solutions
Current Gene Therapy Glycodendrimer PPI as a Potential Drug in Chronic Lymphocytic Leukaemia. The Influence of Glycodendrimer on Apoptosis in In Vitro B-CLL Cells Defined by Microarrays
Anti-Cancer Agents in Medicinal Chemistry The Shape of the Messenger: Using Protein Structure Information to Design Novel Cytokine-based Therapeutics
Current Pharmaceutical Design Natural Product Origins of Hsp90 Inhibitors
Current Cancer Drug Targets Subject Index To Volume 13
Current Medicinal Chemistry Chemical Advances in Therapeutic Application of Exosomes and Liposomes
Current Medicinal Chemistry Targeting the BH3 Domain of Bcl-2 Family Proteins. A Brief History From Natural Products to Foldamers As Promising Cancer Therapeutic Avenues
Current Medicinal Chemistry Myelodysplastic Syndromes: Review of Pathophysiology and Current Novel Treatment Approaches
Current Cancer Drug Targets Chronic Diseases and COVID-19: A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets The Delivery of Biologically Active (Therapeutic) Peptides and Proteins into Cells
Current Medicinal Chemistry Therapies of Hematological Malignancies: An Overview of the Potential Targets and Their Inhibitors
Current Chemical Biology Vascular Endothelial Growth Factor (VEGF) as a Target of Bevacizumab in Cancer: From the Biology to the Clinic
Current Medicinal Chemistry Microenvironmental Regulation of Cancer Stem Cell Phenotypes
Current Stem Cell Research & Therapy