Login

Journal Image
Combinatorial Chemistry & High Throughput Screening
ISSN (Print): 1386-2073
ISSN (Online): 1875-5402
VOLUME: 17
ISSUE: 4
DOI: 10.2174/1386207317666140323133018









The Technology Development Studio of the MPI-CBG: An Open Access Cell-Based Screening Facility

img
Author(s): Marc Bickle
Pages 322-327 (6)
Abstract:
In the past decade, academic screening centers have been created in many universities worldwide. Most of these screening centers are organized as core facilities that accept projects from both within their organization and from external users in order to maximize staff and instrument usage. The Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, also created such a screening facility named the Technology Development Studio (TDS). The mission of the facility is to provide cell based screening services focused on high resolution confocal imaging. The acquisition of high resolution images allows the mathematical description of cells with image analysis to a high degree of precision. This precision in turn allows classifying phenotypes accurately and compare different cellular treatments to discover underlying mechanisms.
Keywords:
Chemical screening, complex biology, high content screening, multi parametric statistics, RNAi.
Affiliation:
Technology Development Studio, Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D-01307, Dresden, Germany.