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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Functional Genomics Down Under: RNAi Screening in the Victorian Centre for Functional Genomics

Author(s): Daniel W. Thomas, Cathryn M. Gould, Yanny Handoko and Kaylene J. Simpson

Volume 17, Issue 4, 2014

Page: [343 - 355] Pages: 13

DOI: 10.2174/1386207317666140323134315

Price: $65

Abstract

The Victorian Centre for Functional Genomics (VCFG) is an RNAi screening facility housed at the Peter MacCallum Cancer Centre in Melbourne, Australia. The Peter Mac is Australia’s largest dedicated Cancer Research Institute, home to a team of over 520 scientists that focus on understanding the genetic risk of cancer, the molecular events regulating cancer growth and dissemination and improving detection through new diagnostic tools (www.petermac.org). Peter Mac is a well recognised technology leader and established the VCFG with a view to enabling researchers Australia and New Zealand-wide access to cutting edge functional genomics technology, infrastructure and expertise. This review documents the technology platforms operated within the VCFG and provides insight into the workflows and analysis pipelines currently in operation.

Keywords: RNAi, functional genomics, high throughput screening, high content imaging.


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