In theoretical physics, there exist two basic mathematical approaches, algebraic and geometrical methods,
which, in most cases, are complementary. In the area of genome sequence analysis, however, algebraic approaches have
been widely used, while geometrical approaches have been less explored for a long time. The Z-curve theory is a geometrical
approach to genome analysis. The Z-curve is a three-dimensional curve that represents a given DNA sequence in the
sense that each can be uniquely reconstructed given the other. The Z-curve, therefore, contains all the information that the
corresponding DNA sequence carries. The analysis of a DNA sequence can then be performed through studying the corresponding
Z-curve. The Z-curve method has found applications in a wide range of areas in the past two decades, including
the identifications of protein-coding genes, replication origins, horizontally-transferred genomic islands, promoters, translational
start sides and isochores, as well as studies on phylogenetics, genome visualization and comparative genomics.
Here, we review the progress of Z-curve studies from aspects of both theory and applications in genome analysis.
GC profile, Gene finding, Genomic island, Replication origin, Z-curve.
Center for Molecular Medicine and Genetics, Wayne State University Medical School, Detroit, MI 48201, USA.