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Current Topics in Medicinal Chemistry
ISSN (Print): 1568-0266
ISSN (Online): 1873-5294
VOLUME: 14
ISSUE: 9
DOI: 10.2174/1568026614666140329224243      Price:  $58









PEGylated Polyester-Based Nanoncologicals

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Author(s): Claudia Conte, Ivana d’Angelo, Agnese Miro, Francesca Ungaro and Fabiana Quaglia
Pages 1097-1114 (18)
Abstract:
Several PEGylated polyester-based nanoncologicals have been proposed in the literature, some of them nowadays being under preclinical/clinical trials or marketed. In this review, we describe the main features of PEGylated polyesters and their correspondent nanocarriers. A first part is devoted to intravenously injectable PEGylated nanocarriers, which represent the systems most investigated so far. After describing fundamental design rules dictated by the administration route, PEGylated nanocarriers currently under preclinical/clinical investigation or in the market will be described from a technological point of view and related therapeutic implications discussed. Finally, new perspective of use of PEGylated nanocarriers for oral and pulmonary delivery of anticancer drugs will be considered.
Graphical Abstract:
Keywords:
Cancer, chemotherapeutics, drug targeting, nanoparticles, nanotechnology, polyethylenglycol, polymers.
Affiliation:
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli – Italy.