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Current Microwave Chemistry
ISSN (Print): 2213-3356
ISSN (Online): 2213-3364
VOLUME: 1
ISSUE: 1
DOI: 10.2174/2213335601666140402002204









Microwave Assisted Synthesis of ethyl-quinolon-4-one-3-carboxylates and Hydrolysis to quinolon-4-one-3-carboxylic Acids

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Author(s): Ivana Malvacio, D. Mariano. A. Vera and Elizabeth L. Moyano
Pages 52-58 (7)
Abstract:
A fast and efficient microwave assisted synthesis of several ethyl-quinolon-4-one-3-carboxylates and quinolon- 4-one-3-carboxylic acids has been developed. The 3-carboethoxy quinolones are easily obtained in a one-pot procedure through the cyclization of aminomethylenemalonate intermediates obtained by reaction of different p-substituted anilines and diethyl-ethoxymethylenmalonate. These quinolones are then irradiated under base hydrolysis conditions to get the carboxylic acids through a very fast and clean approach.
Graphical Abstract:
Keywords:
Carboxylic acids, catalysis, cyclization, hydrolysis, malonates, microwave, open-vessel, quinolones, sealed-vessel, thermolysis.
Affiliation:
INFIQC - Organic Chemistry Department, School of Chemical Sciences, National University of Cordoba, Cordoba, CP 5000, Argentine.