Login

Journal Image
Current Cancer Drug Targets
ISSN (Print): 1568-0096
ISSN (Online): 1873-5576
VOLUME: 14
ISSUE: 4
DOI: 10.2174/1568009614666140407113124      Price:  $58









Metabolic Features of Melanoma: A Gold Mine of New Therapeutic Targets?

img
Author(s): Philippe Marchetti, Pierre Guerreschi, Jerome Kluza and Laurent Mortier
Pages 357-370 (14)
Abstract:
In recent years, our knowledge regarding the metabolism of melanoma has greatly advanced and consequently new therapeutic strategies are being developed. This review is focused on metabolic pathways contributing to melanoma proliferation, the influence of BRAF inhibitors on those metabolic pathways and finally a presentation of potential therapeutic strategies aimed at blocking metabolic signaling pathways and therefore melanoma development.
Keywords:
Glycolysis, mitochondria, oxidative stress, warburg.
Affiliation:
INSERM U 837 Faculte de Medecine, 1, place Verdun F- 59045 Lille Cedex, France.