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Current Drug Delivery
ISSN (Print): 1567-2018
ISSN (Online): 1875-5704
VOLUME: 11
ISSUE: 6
DOI: 10.2174/1567201811666140414120002      Price:  $58









Antibiotic Releasing Biodegradable Scaffolds for Osteomyelitis

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Author(s): Manitha Nair and Amit Krishnan
Pages 687-700 (14)
Abstract:
Osteomyelitis is characterized by progressive inflammatory bone degeneration. In the management of chronic osteomyelitis, it is necessary to remove the infected bone tissue followed by implantation of an antibiotic releasing biomaterial that can release antibiotic locally for long periods of time. The main carrier used in clinics for this application is polymethylmethacrylate (PMMA) (Eg. Septopal beads). However, major drawback is the need of an additional surgery to remove the beads after therapy, as PMMA is not biodegradable. This necessitates the requirement of biodegradable carrier systems that can release antibiotics and simultaneously support debrided bone formation. This review summarizes biodegradable carrier systems that have been reported for the localised treatment and prophylaxis of osteomyelitis.
Graphical Abstract:
Keywords:
Bacterial internalization, biodegradable scaffolds, osteomyelitis, staphylococcus aureus.
Affiliation:
Amrita Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Science & Research Center, Amrita Vishwa Vidyapeetham University, Cochin, Kerala 682041, India.