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Current Pharmaceutical Design
ISSN (Print): 1381-6128
ISSN (Online): 1873-4286
Epub Full Text Article
DOI: 10.2174/1381612820666140417095730      Price:  $95









New Insight into Urate-Related Mechanism of Cardiovascular Damage

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Author(s): Davide Grassi, Giovambattista Desideri and Claudio Ferri
Abstract:
Several experimental and clinical studies reported that hyperuricemiamay trigger hypertension, metabolicsyndrome, vascular damage and renal disease. Furthermore, a substantialproportion of epidemiological studies are compatible withthe hypothesis that hyperuricemia may be an indipendent risk factor for cardiovascular diseaseas wellas for an increased cardiovascular mortality.Xanthine oxidase isa critical source of reactive oxygen species contributing to vascular inflammation and endothelial dysfunction.Although a causal relationshipbetween these conditions has not been clearly clarified, the capacity of uric acid to negatively affect vascular function by pro-oxidant effects and by decreasing nitric oxide bioavailability and consequently induce endothelial dysfunction may explain the association among hyperuricemia, hypertension, the metabolic syndrome, and cardiovascular disease, also by a common mechanicistic point of view
Keywords:
Uric acid, hyperuricemia, endothelial dysfunction, oxidative stress, cardiovascular risk
Affiliation:
University of L’Aquila, Department of Life, Health, and Environmental Sciences, Viale S Salvatore, Delta 6 Medicina, 67100 Coppito, L’Aquila, Italy