Abstract
Arterial stiffness is independently associated with increased cardiovascular risk in patients with cardiovascular risk factors and in the general population. Metabolic syndrome (MetS) is frequently characterized by increased arterial stiffness since all components of MetS are implicated in the pathogenesis of arterial stiffness. We review the management of arterial stiffness in patients with MetS. Several small, short-term studies showed that lifestyle changes, antidiabetic, antihypertensive and lipid-lowering agents improve arterial elasticity. However, differences appear to exist between different classes of agents, with statins and inhibitors of the renin-angiotensinaldosterone system having the more favorable effects on arterial stiffness. A multifactorial approach appears to be the optimal management of increased arterial stiffness in patients with MetS.
Keywords: Arterial stiffness, metabolic syndrome, lifestyle changes, statins, angiotensin converting enzyme inhibitors, angiotensin receptor blockers.
Current Pharmaceutical Design
Title:Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome
Volume: 20 Issue: 39
Author(s): Konstantinos Tziomalos, Vasilios G. Athyros and Asterios Karagiannis
Affiliation:
Keywords: Arterial stiffness, metabolic syndrome, lifestyle changes, statins, angiotensin converting enzyme inhibitors, angiotensin receptor blockers.
Abstract: Arterial stiffness is independently associated with increased cardiovascular risk in patients with cardiovascular risk factors and in the general population. Metabolic syndrome (MetS) is frequently characterized by increased arterial stiffness since all components of MetS are implicated in the pathogenesis of arterial stiffness. We review the management of arterial stiffness in patients with MetS. Several small, short-term studies showed that lifestyle changes, antidiabetic, antihypertensive and lipid-lowering agents improve arterial elasticity. However, differences appear to exist between different classes of agents, with statins and inhibitors of the renin-angiotensinaldosterone system having the more favorable effects on arterial stiffness. A multifactorial approach appears to be the optimal management of increased arterial stiffness in patients with MetS.
Export Options
About this article
Cite this article as:
Tziomalos Konstantinos, Athyros G. Vasilios and Karagiannis Asterios, Treating Arterial Stiffness in Young and Elderly Patients with the Metabolic Syndrome, Current Pharmaceutical Design 2014; 20 (39) . https://dx.doi.org/10.2174/1381612820666140417101523
DOI https://dx.doi.org/10.2174/1381612820666140417101523 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Gene therapy for Multiple Myeloma
Current Gene Therapy Familial Combined Hyperlipidaemia: Under - Defined and Under - Diagnosed?
Current Vascular Pharmacology Recent Advances in Synthetic Chemistry of Diabetic Research
Mini-Reviews in Medicinal Chemistry Bacterial Adaptation and Infection
Inflammation & Allergy - Drug Targets (Discontinued) Neuromuscular Disorders in Left Ventricular Hypertrabeculation/Noncompaction
Current Pharmaceutical Design Extracorporeal Lung Assist for Sepsis and Acute Respiratory Distress Syndrome
Cardiovascular & Hematological Disorders-Drug Targets Tricyclic Structures in Medicinal Chemistry: An Overview of their Recent Uses in Non-CNS Pathologies
Mini-Reviews in Medicinal Chemistry Interactions Between Growth Hormone and the Thyroid Gland - with Special Reference to Biochemical Diagnosis
Current Medicinal Chemistry Readjusting the Glucocorticoid Balance: An Opportunity for Modulators of 11β -Hydroxysteroid Dehydrogenase Type 1 Activity?
Endocrine, Metabolic & Immune Disorders - Drug Targets The Role of SHP-2 in Cell Signalling and Human Disease
Current Enzyme Inhibition Therapeutic Targets for the Management of Peripheral Nerve Injury- Induced Neuropathic Pain
CNS & Neurological Disorders - Drug Targets Effect of Glycine on Adipocyte Hypertrophy in a Metabolic Syndrome Rat Model
Current Drug Delivery Cytokines and their Antagonists as Therapeutic Agents
Current Medicinal Chemistry Chemokines and Defensins as HIV Suppressive Factors: An Evolving Story
Current Pharmaceutical Design Ivermectin in Human Medicine, An Overview of the Current Status of Its Clinical Applications
Current Pharmaceutical Biotechnology Evaluating a Child with Partial Developmental Delay (ParDD), Global Developmental Delay (GDD)/Mental Retardation (MR): Clinical Expertise Based or Evidence-Based?
Current Pediatric Reviews Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?
CNS & Neurological Disorders - Drug Targets Effects of Acarbose on Proinsulin and Insulin Secretion and their Potential Significance for the Intermediary Metabolism and Cardiovascular System
Current Diabetes Reviews Development of DNA Methyltransferase Inhibitors for the Treatment of Neoplastic Diseases
Current Medicinal Chemistry Recent Developments of Flavonoids with Various Activities
Current Topics in Medicinal Chemistry