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Current Catalysis
ISSN (Print): 2211-5447
ISSN (Online): 2211-5455
VOLUME: 3
ISSUE: 3
DOI: 10.2174/2211544703666140417230832









Deep Eutectic Mixture Catalyzed One-Pot Three-Component Synthesis of 1H-pyrazolo and 2H-indazolo Phthalazines

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Author(s): Atul Chaskar
Pages 266-273 (8)
Abstract:
A direct, simple and green protocol describes synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones and 2Hindazolo[ 2,1-b] phthalazine-triones derivatives using deep eutectic mixture (choline chloride: malonic acid) as a homogeneous catalyst as well as solvent at reflux temperature. This method provides significant advantages such as short reaction time, easy workup, and high yield of product, atom economy and recyclability of catalyst.
Graphical Abstract:
Keywords:
Aldehydes, aqueous medium, deep eutectic mixture, 2, 3-dihydrophthalazine-1, 4-dione, 5, 5-dimethylcyclohexane- 1, 3-dione, ethylcyanoacetate, malononitrile.
Affiliation:
Department of Dyestuff Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai - 400 019, India.