Diagnostic und Therapeutic Value of Cell-free Circulating DNA as a Non-invasive Biomarker in Patients with Prostate Cancer
Stefan Latz, Stefan C. Muller and Jorg Ellinger
Pages 258-264 (7)
The presence of small amounts of circulating DNA in plasma was demonstrated 60 years ago. Since then, cellfree
DNA has been tested for quantity, fragmentation pattern and tumor-specific sequences in patients with various malignancies.
The introduction of improved detection methods showed that all these alterations are regularly detectable in many
cancer patients and the investigation of cell-free DNA may provide useful diagnostic and prognostic information. Herein,
we review the recent findings on cell-free DNA alterations in patients with prostate cancer and discuss its diagnostic and
Prostate cancer, DNA fragmentation, cell-free DNA, DNA methylation, allelic imbalance.
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Sigmund-Freud- Strasse 25, 53105 Bonn, Germany.