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Current Topics in Medicinal Chemistry
ISSN (Print): 1568-0266
ISSN (Online): 1873-5294
VOLUME: 14
ISSUE: 10
DOI: 10.2174/1568026614666140423101226      Price:  $58









Conformational Preferences of Chiral Acyclic Homooligomeric β2,2-Peptides

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Author(s): Fernando Rodriguez, Francisco Corzana, Alberto Avenoza, Jesus Hector Busto, Jesus Manuel Peregrina and Maria del Mar Zurbano
Pages 1225-1234 (10)
Abstract:
α-Methylisoserine, a chiral acyclic quaternary β-amino acid, has been used to mimic secondary structures, when it is incorporated in a homogeneous β2,2-dipeptide. In particular, the observed folded conformations in aqueous solution can be regarded as mimics of β-turn.
Graphical Abstract:
Keywords:
β-Peptides, conformational analysis, molecular dynamics, nuclear magnetic resonance.
Affiliation:
Departamento de Quimica, Universidad de La Rioja, Centro de Investigacion en Sintesis Quimica, C/ Madre de Dios, 51. 26006 Logrono (La Rioja). Spain.