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Current Topics in Medicinal Chemistry
ISSN (Print): 1568-0266
ISSN (Online): 1873-5294
VOLUME: 14
ISSUE: 10
DOI: 10.2174/1568026614666140423103848      Price:  $58









Enantioselective Synthesis in Carbohydrate-Based Drug Discovery: Imino Sugars, Alkaloids and Macrolide Antibiotics

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Author(s): Nuno M. Xavier and Amélia P. Rauter
Pages 1235-1243 (9)
Abstract:
This review is dedicated to enantioselective methods for the generation of carbohydrate-based lead compounds for drug research. Selected examples encompassing imino sugars, bicyclic imino sugar-type alkaloids such as castanospermine, swainsonine, or alexine, as well as macrolide glycosides are covered and discussed.
Graphical Abstract:
Keywords:
Alkaloids, carbohydrates, enantioselective synthesis, imino sugars, macrolide glycosides.
Affiliation:
Centro de Quimica e Bioquimica, Faculdade de Ciencias, Universidade de Lisboa, Campo Grande, Edificio C8, 5º Piso, 1749-016 Lisboa, Portugal.