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Current Topics in Medicinal Chemistry
ISSN (Print): 1568-0266
ISSN (Online): 1873-5294
VOLUME: 14
ISSUE: 10
DOI: 10.2174/1568026614666140423112145      Price:  $58









Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes

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Author(s): Carmen Nejera and Jose M. Sansano
Pages 1271-1282 (12)
Abstract:
This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective strategies is described remarking the scope and main features of each one.
Graphical Abstract:
Keywords:
Antitumoral, asymmetric synthesis, catalysis, cycloaddition, metal, organocatalyst.
Affiliation:
Departamento de Quimica Organica and Instituto de Sintesis Organica (ISO). Universidad de Alicante, E-03080-Alicante, Spain.