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Current Molecular Imaging
ISSN (Print): 2211-5552
ISSN (Online): 2211-5544
Epub Full Text Article
DOI: 10.2174/2211555203666140423225138      Price:  $95









Correlation between Changes of FDG-PET findings and those of Mini-Mental Status Examination Scores in Patients with Moderate Alzheimer’s Disease: Usefulness of Stereotactic Extraction Estimation

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Author(s): Nobuhiko Miyazawa
Abstract:
Purpose: To investigate the association between changes on [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) and clinical deterioration in patients with moderate Alzheimer’s disease (AD), findings of FDG-PET in the first and follow-up stages were compared using stereotactic extraction estimation (SEE) and three-dimensional stereotactic surface projection (3D-SSP).

Methods and patients: Thirty consecutive patients with AD examined twice by FDG-PET were divided into two groups with improved or stable mini-mental state examination (MMSE) (SI group, 14 patients) and deteriorated MMSE (D group, 16 patients). Statistical analysis using SEE in 3D-SSP was used to investigate the changes in Z-score in the frontal, parietal, temporal, and occipital lobes, precuneus, and posterior cingulate cortex (PCC).

Results: Changes in Z-scores in the PCC (p=0.0006) and temporal lobe (p=0.021) were significantly higher in the D group than in the SI group. Z-score was significantly higher in the left PCC compared to the right PCC (p=0.0097).

Conclusions: SEE in 3D-SSP is the helpful method to detect the regional differences. Metabolic reduction on FDG-PET in the left PCC detected by SEE and 3D-SSP is associated with clinical deterioration in patients with moderate AD.

Keywords:
Alzheimer’s disease, FDG-PET, Stereotactic extraction estimation, 3D-SSP
Affiliation:
Department of PET Center, Kofu Neurosurgical Hospital, Kofu, Yamanashi, Japan.