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Letters in Drug Design & Discovery
ISSN (Print): 1570-1808
ISSN (Online): 1875-628X
VOLUME: 11
ISSUE: 8
DOI: 10.2174/1570180811666140506204239      Price:  $58









Synthesis and Antimycobacterial Activity of Highly Functionalised Pyrrolothiazole Derivatives

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Author(s): Abdulrahman I. Almansour, Venu Sanjeevi Lakshmipathi, Elumalai Manogaran, Mohamed Ashraf Ali, Farzana Beevi, Tan Soo Choon, Ang Chee Wei, Raju Suresh Kumar and Mohammad Asad
Pages 968-974 (7)
Abstract:
A series of twelve pyrralothiazoles was synthesized using [3+2]- cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1µM. Compound (4d) was found to be the most active with MIC of 0.231 µM and 4.372 µM respectively.
Graphical Abstract:
Keywords:
[3+2]-cycloaddition, Antimycobacterial activity, Azomethine ylide, Dispiroheterocycle, Intermolecular.
Affiliation:
New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan-301030, India.