Abstract
Although innate immunity primarily combats systemic infections of opportunistic fungi such as Aspergillus and Candida spp., acquired and protective immunoreactions were observed long ago in animal trials following sublethal systemic infections caused by viable fungi or after challenging animals with inactivated fungal cells. Based on these observations, fungal antigens should exist which mediate such protective immunoreactions and have in part already been identified. In this context, this review focuses primarily on the various approaches that have been used to identify protectionmediating Aspergillus-antigens and their rationale. Emphasis is placed on screening methods that have exploited genetic or proteomic approaches on the basis of the corresponding fungal genome projects. Thereby, a survey and description is given of the antigens so far known to be capable of inducing immune responses that protect animals against acquiring lethal systemic aspergillosis.
Keywords: Aspergillus fumigatus. fungus, immunity, protective antigens, vaccine.
Current Protein & Peptide Science
Title:Vaccination Approaches Against Opportunistic Fungal Infections Caused by Aspergillus fumigatus
Volume: 15 Issue: 5
Author(s): Utz Reichard, Sahra Herrmann and Abdul R. Asif
Affiliation:
Keywords: Aspergillus fumigatus. fungus, immunity, protective antigens, vaccine.
Abstract: Although innate immunity primarily combats systemic infections of opportunistic fungi such as Aspergillus and Candida spp., acquired and protective immunoreactions were observed long ago in animal trials following sublethal systemic infections caused by viable fungi or after challenging animals with inactivated fungal cells. Based on these observations, fungal antigens should exist which mediate such protective immunoreactions and have in part already been identified. In this context, this review focuses primarily on the various approaches that have been used to identify protectionmediating Aspergillus-antigens and their rationale. Emphasis is placed on screening methods that have exploited genetic or proteomic approaches on the basis of the corresponding fungal genome projects. Thereby, a survey and description is given of the antigens so far known to be capable of inducing immune responses that protect animals against acquiring lethal systemic aspergillosis.
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Cite this article as:
Reichard Utz, Herrmann Sahra and Asif R. Abdul, Vaccination Approaches Against Opportunistic Fungal Infections Caused by Aspergillus fumigatus, Current Protein & Peptide Science 2014; 15 (5) . https://dx.doi.org/10.2174/1389203715666140512122037
DOI https://dx.doi.org/10.2174/1389203715666140512122037 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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