Login

Journal Image
Letters in Organic Chemistry
ISSN (Print): 1570-1786
ISSN (Online): 1875-6255
VOLUME: 11
ISSUE: 8
DOI: 10.2174/1570178611666140512215136      Price:  $58









Synthesis of 3-substituted Coumarins: An Efficient Green Approach Using L-proline as Catalyst in Triethanolamine Medium

img
Author(s): Devulapally Srikrishna, Syed Tasqeeruddin and Pramod Kumar Dubey
Pages 556-563 (8)
Abstract:
3-Substituted coumarins were synthesized very efficiently, using Knoevenagel method from salicylaldehydes 1 and active methylene compounds 2 under green conditions. The effect of catalyst and solvent on this condensation was studied. L-proline was found to be the best catalyst and triethanolamine the best reaction medium for this reaction.
Graphical Abstract:
Keywords:
Salicylaldehydes, active methylene compounds, L-proline, triethanolamine, coumarins, Knoevenagel condensation.
Affiliation:
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad College of Engineering, Kukatpally, Hyderabad, India - 500085.