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Current Neurovascular Research
ISSN (Print): 1567-2026
ISSN (Online): 1875-5739
VOLUME: 11
ISSUE: 3
DOI: 10.2174/1567202611666140520151002      Price:  $58









Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death

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Author(s): Pradeep Hanumanthappa, Asha Densi and Rajanikant Golgodu Krishnamurthy
Pages 271-278 (8)
Abstract:
Glycogen synthase kinase 3β (GSK-3β) is implicated in diverse cellular processes such as cell signaling and survival. Accumulating lines of evidence indicate that increased GSK-3β activity contributes to neuronal death and pathogenesis of ischemic stroke. Considering predominant roles of GSK-3β in neuronal apoptosis, modulation of this protein kinase is a reliable strategy for ischemic neuroprotection. In this review, we survey and synthesize the current knowledge about the role of GSK-3β in neuroprotection following the ischemic stroke.
Keywords:
Apoptosis, brain, GSK-3β, hypoxia, ischemic stroke, neuronal death.
Affiliation:
Associate Professor & Head, School of Biotechnology, Coordinator, DBT - Centre for Bioinformatics, National Institute of Technology Calicut, Calicut - 673601, India.