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Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)
ISSN (Print): 1871-5206
ISSN (Online): 1875-5992
VOLUME: 14
ISSUE: 6
DOI: 10.2174/1871520614666140521120811      Price:  $58









Garlic-Derived Allyl Sulfides in Cancer Therapy

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Author(s): Hai-Xia Cao, Ke-Xiang Zhu, Jian-Gao Fan and Liang Qiao
Pages 793-799 (7)
Abstract:
Garlic (Allium sativam L.) is widely used in traditional herbal remedies and alternative medicine. The potential health benefits of garlic are largely attributed to its metabolic byproducts. Extensive in vivo and in vitro studies has demonstrated that the garlic derivatives possess anti-cancer effects, but the underlying mechanisms are not completely understood. In this mini-review, we aim to summarize the reported biological effects of garlic products as anti-tumor agents, and present the possible molecular mechanisms responsible for the anti-carcinogenesis effects of garlic and its derivatives.
Keywords:
Allyl sulfides, apoptosis, carcinogenesis, cell cycle, Garlic, organosulfur compounds.
Affiliation:
Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of medicine, Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China.