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Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)
ISSN (Print): 1871-5206
ISSN (Online): 1875-5992
VOLUME: 14
ISSUE: 6
DOI: 10.2174/1871520614666140521122932      Price:  $58









Nanoparticle-Delivered Quercetin for Cancer Therapy

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Author(s): Ke Men, Xingmei Duan, Xia Wei Wei, Ma Ling Gou, Mei Juan Huang, Li Juan Chen, Zhi Yong Qian and Yu Quan Wei
Pages 826-832 (7)
Abstract:
Quercetin, a natural protective bioflavonoid, possesses diverse pharmacologic effects, such as antioxidant, anti-inflammatory, anti-proliferative, and anti-angiogenic activities. Recently, quercetin’s effect in cancer prevention and treatment was recognized. However, the poor water solubility and low-bioavailability of quercetin limit its clinical use in cancer therapy. Nanotechnology provides a method to create novel formulations for hydrophobic drug. Nanoparticles-delivered quercetin has attracted many attentions for its enhanced anticancer potential and promising clinical application. This review will discuss the application of nanotechnology in quercetin delivery for cancer therapy.
Keywords:
Cancer therapy, nanoparticle, nanotechnology, quercetin.
Affiliation:
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, People’s Republic of China.