Abstract
MicroRNAs post-transcriptionally regulate the expression of approximately 60% of the mammalian genes, and have an important role in maintaining the differentiated state of somatic cells through the expression of unique tissuespecific microRNA sets. Likewise, the stemness of pluripotent cells is also sustained by embryonic stem cell-enriched microRNAs, which regulate genes involved in cell cycle, cell signaling and epigenetics, among others. Thus, microRNAs work as modulator molecules that ensure the appropriate expression profile of each cell type. Manipulation of microRNA expression might determine the cell fate. Indeed, microRNA-mediated reprogramming can change the differentiated status of somatic cells towards stemness or, conversely, microRNAs can also transform stem- into differentiated-cells both in vitro and in vivo. In this Review, we outline what is currently known in this field, focusing on the applications of microRNA in tissue engineering.
Keywords: Cell fate, ESC, iPSC, microRNA, stemness, tissue engineering.
MicroRNA
Title:MicroRNAs: Modulators of Cell Identity, and their Applications in Tissue Engineering
Volume: 3 Issue: 1
Author(s): Amanda O. Ribeiro, Claudia R. G. Schoof, Alberto Izzotti, Lygia V. Pereira and Luciana R. Vasques
Affiliation:
Keywords: Cell fate, ESC, iPSC, microRNA, stemness, tissue engineering.
Abstract: MicroRNAs post-transcriptionally regulate the expression of approximately 60% of the mammalian genes, and have an important role in maintaining the differentiated state of somatic cells through the expression of unique tissuespecific microRNA sets. Likewise, the stemness of pluripotent cells is also sustained by embryonic stem cell-enriched microRNAs, which regulate genes involved in cell cycle, cell signaling and epigenetics, among others. Thus, microRNAs work as modulator molecules that ensure the appropriate expression profile of each cell type. Manipulation of microRNA expression might determine the cell fate. Indeed, microRNA-mediated reprogramming can change the differentiated status of somatic cells towards stemness or, conversely, microRNAs can also transform stem- into differentiated-cells both in vitro and in vivo. In this Review, we outline what is currently known in this field, focusing on the applications of microRNA in tissue engineering.
Export Options
About this article
Cite this article as:
Ribeiro O. Amanda, Schoof R. G. Claudia, Izzotti Alberto, Pereira V. Lygia and Vasques R. Luciana, MicroRNAs: Modulators of Cell Identity, and their Applications in Tissue Engineering, MicroRNA 2014; 3 (1) . https://dx.doi.org/10.2174/2211536603666140522003539
DOI https://dx.doi.org/10.2174/2211536603666140522003539 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sirolimus and its Analogs and its Effects on Vascular Diseases
Current Pharmaceutical Design Stem Cell Function, Self-Renewal, Heterogeneity, and Regenerative Potential in Skeletal Muscle Stem Cells
Recent Patents on Regenerative Medicine A Closer Look at Protein Transduction Domains as a Tool in Drug Delivery
Current Nanoscience The Neuroendocrine System as a Model to Evaluate Experimental Gene Therapy
Current Gene Therapy Role of the Retinoblastoma Tumor Suppressor in the Maintenance of Genome Integrity
Current Molecular Medicine IP6 & Inositol in Cancer Prevention and Therapy
Current Cancer Therapy Reviews Pharmacology and Therapeutic Applications of Enediyne Antitumor Antibiotics
Current Molecular Pharmacology Potential Therapeutic Targets of Curcumin, Most Abundant Active Compound of Turmeric Spice: Role in the Management of Various Types of Cancer
Recent Patents on Anti-Cancer Drug Discovery 1,2,3-Triazine Scaffold as a Potent Biologically Active Moiety: A Mini Review
Mini-Reviews in Medicinal Chemistry Chemopreventive Properties and Molecular Mechanisms of the Bioactive Compounds in Hibiscus Sabdariffa Linne
Current Medicinal Chemistry Histone Acetylation / Deacetylation and Cancer: An “Open” and “Shut” Case?
Current Molecular Medicine Possible Physiopathological Effects of the Transglutaminase Activity on the Molecular Mechanisms Responsible for Human Neurodegenerative Diseases
Recent Patents on CNS Drug Discovery (Discontinued) Development of Genetic Testing for Breast, Ovarian and Colorectal Cancer Predisposition: A Step Closer to Targeted Cancer Prevention
Current Drug Targets Addressing the Challenge: Current and Future Directions in Ovarian Cancer Therapy
Current Gene Therapy Overview of PCTK3/CDK18: A Cyclin-Dependent Kinase Involved in Specific Functions in Post-Mitotic Cells
Current Medicinal Chemistry Role of Membrane Transporters and Metabolizing Enzymes in Ocular Drug Delivery
Current Drug Metabolism Pharmacological Modulation of Diacylglycerol-Sensitive TRPC3/6/7 Channels
Current Pharmaceutical Biotechnology Promoters and Control Elements: Designing Expression Cassettes for Gene Therapy
Current Gene Therapy Toward a Discipline of Pharmacoepigenomics
Current Pharmacogenomics Aptamers in Targeted Nanotherapy
Current Topics in Medicinal Chemistry