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Current Respiratory Medicine Reviews
ISSN (Print): 1573-398X
ISSN (Online): 1875-6387
VOLUME: 9
ISSUE: 5
DOI: 10.2174/1573398X10666140526235154









The Use of Colchicine in Respiratory Diseases

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Author(s): Ori-Michael J. Benhamou, Shahar Geva, Miriam Jacobs, Jonathan Drew, Maor Waldman and Or Kalchiem-Dekel
Pages 300-304 (5)
Abstract:
The nitrogen-containing compound, colchicine, has been used medicinally for millennia. It was first isolated from the plant Colchicum autumnale, by the French chemists P.S. Pelletier and J. Caventon. Today, colchicine is primarily used for the treatment of gout and auto-inflammatory diseases, such as familial Mediterranean fever (FMF), but it has been also investigated for its therapeutic utility in a number of respiratory diseases such as asthma, chonic obstructive pulmonary disease and idiopathic pulmonary fibrosis. While colchicine has shown some promise as an adjuvant to corticosteroid treatment, the benefit of the drug remains to be elucidated. The lack of serious adverse effects of oral colchicine at therapeutic levels should ease the design of more specific trials.
Graphical Abstract:
Keywords:
Asthma, chronic obstructive pulmonary diease, colchicine, idiopathic pulmonary fibrosis.
Affiliation:
Department of Internal Medicine B, Soroka University Medical Center, Beer-Sheva 84101, Israel.