Abstract
This review discusses concepts towards facile non-enzymatic glycosylation of unprotected or lightly protected glycostructures. These comprise approaches in which reactivity distinction of hydroxyl groups is achieved via stannylene or boronic and borinic acid intermediates as well as via oxyanion formation along with syntheses based on selectivity implemented by the substrates themselves. Further, syntheses of complex glycostructures and oligosaccharides are shown, as well as the concept of random glycosylation towards glycoside libraries with desired equal product distribution.
Keywords: Base promoted, boronic/borinic acid mediated, glycosylation, random approach, stannylene-mediated, substance controlled, unprotected/partially protected acceptors.
Current Organic Chemistry
Title:Glycosylation Employing Unprotected Carbohydrate Acceptor Components
Volume: 18 Issue: 14
Author(s): Stephan Bottcher and Joachim Thiem
Affiliation:
Keywords: Base promoted, boronic/borinic acid mediated, glycosylation, random approach, stannylene-mediated, substance controlled, unprotected/partially protected acceptors.
Abstract: This review discusses concepts towards facile non-enzymatic glycosylation of unprotected or lightly protected glycostructures. These comprise approaches in which reactivity distinction of hydroxyl groups is achieved via stannylene or boronic and borinic acid intermediates as well as via oxyanion formation along with syntheses based on selectivity implemented by the substrates themselves. Further, syntheses of complex glycostructures and oligosaccharides are shown, as well as the concept of random glycosylation towards glycoside libraries with desired equal product distribution.
Export Options
About this article
Cite this article as:
Bottcher Stephan and Thiem Joachim, Glycosylation Employing Unprotected Carbohydrate Acceptor Components, Current Organic Chemistry 2014; 18 (14) . https://dx.doi.org/10.2174/1385272819666140527231701
DOI https://dx.doi.org/10.2174/1385272819666140527231701 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pharmacological Aspects and Potential Use of Phloretin: A Systemic Review
Mini-Reviews in Medicinal Chemistry Are Viruses and Parasites Linked to Celiac Disease? A Question that Still has no Definite Answer
Current Pharmaceutical Biotechnology Challenges Associated with Current and Future TB Treatment
Infectious Disorders - Drug Targets Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: A Potential New Approach to Tackle <i>Mycobacterium tuberculosis</i>
Current Topics in Medicinal Chemistry Computational Insight into the Binding Mechanism of Pyrazinoic Acid to RpsA Protein
Current Chinese Science Pharmacophore-based Screening for Identification of Human Acyl-CoA Cholesterol Acyltransferase Inhibitors: An In-silico Study
Letters in Drug Design & Discovery Biological Activities of Pyrazoline Derivatives -A Recent Development
Recent Patents on Anti-Infective Drug Discovery A Possible Role for Interleukin 37 in the Pathogenesis of Behcet's Disease
Current Molecular Medicine Assessing the Performance of 3D Pharmacophore Models in Virtual Screening: How Good are They?
Current Topics in Medicinal Chemistry Meet Our Editorial Board Member
Combinatorial Chemistry & High Throughput Screening The 4-Quinolone-3-Carboxylic Acid Motif as a Multivalent Scaffold in Medicinal Chemistry
Current Medicinal Chemistry Predictive In Vitro Models of the Sterilizing Activity of Anti-Tuberculosis Drugs
Current Pharmaceutical Design Pharmacokinetic Evaluation of Callistemon viminalis Derived Natural Compounds as Targeted Inhibitors Against δ -Opioid Receptor and Farnesyl Transferase
Letters in Drug Design & Discovery Molecular Targets of Rheumatoid Arthritis
Inflammation & Allergy - Drug Targets (Discontinued) Syntheses and Antimycobacterial Activities of [(2S,3R)-2-(Amino)-4- (Arenesulfonamido)-3-Hydroxy-1-Phenylbutane Derivatives
Medicinal Chemistry Coumarin-Oxadiazole Derivatives: Synthesis and Pharmacological Properties
Mini-Reviews in Organic Chemistry Vitamin D: A Micronutrient Regulating Genes
Current Pharmaceutical Design Cellular and Molecular Mechanisms of Tumor-Induced T-Cell Tolerance
Current Cancer Drug Targets Kawasakis Disease, Acrodynia, and Mercury
Current Medicinal Chemistry Current Status of Computer-Aided Drug Design for Type 2 Diabetes
Current Computer-Aided Drug Design