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Mini-Reviews in Medicinal Chemistry
ISSN (Print): 1389-5575
ISSN (Online): 1875-5607
VOLUME: 14
ISSUE: 6
DOI: 10.2174/1389557514666140529223436      Price:  $58









The Effects of Caffeine on the Cholinergic System

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Author(s): Miroslav Pohanka
Pages 543-549 (7)
Abstract:
Caffeine is a secondary metabolite of tea and coffee plants. It is the active psychostimulant ingredient of widely consumed beverages, chocolate and some drugs as well. The major pathways for caffeine including interaction with adenosine receptors have been identified but caffeine has several minor pathways as well that remain poorly understood including the cholinergic system. Given the role of caffeine in the cholinergic system, some molecular targets have been tracked and a mechanism of its action has been proposed in research studies. However, the biological effect of caffeine on the cholinergic system is not completely understood. The present review focuses on the role of caffeine in the cholinergic system.
Keywords:
Acetylcholine, acetylcholinesterase, acetylcholine receptor, butyrylcholinesterase, caffeine, cholinergic antiinflammatory pathway.
Affiliation:
Faculty of Military Health Sciences, University of Defence, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic; Karel English College in Brno, Sujanovo namesti 356/1, 60200 Brno, Czech Republic.