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Reviews on Recent Clinical Trials
ISSN (Print): 1574-8871
ISSN (Online): 1876-1038
VOLUME: 9
ISSUE: 2
DOI: 10.2174/1574887109666140530111214









Indacaterol in the Treatment of Chronic Obstructive Pulmonary Disease: From Clinical Trials to Daily Practice

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Author(s): Cristoforo Incorvaia, Erminia Ridolo, Edoardo Riario-Sforza, Marcello Montagni and Gian G. Riario-Sforza
Pages 96-101 (6)
Abstract:
Indacaterol was introduced as an agent of the new generation of very long acting beta2-agonists (VLABA) that provides a 24-hour activity of bronchodilation and allows a once-daily OD dosing. The first trial showed a significantly higher efficacy of indacaterol vs. placebo in patients with chronic obstructive pulmonary disease (COPD). The following trials were aimed at evaluating its performance compared with other bronchodilators. The results can be summarized in a comparable efficacy of indacaterol, mainly assessed by the increase in FEV1 value but also by quality of life and other patient- reported outcomes (PROs), compared with the OD antimuscarinic tiotropium bromide, and in a slightly higher efficacy compared with the LABA formoterol and salmeterol administered twice-daily. No problems of safety and tolerability were reported in the trials as well as in specific studies, every kind of adverse event, including cardiovascular effects, being similarly frequent with indacaterol and with placebo. Concerning the real-life management, in respect to LABA, the OD dosing makes indacaterol more convenient for COPD patients and is likely to positively influence the patient’s adherence. Since adherence to medical treatment of chronic diseases, and particularly COPD is a crucial issue in medicine, such aspect should confer to indacaterol a valuable role in clinical practice. The recently approved combination of indacaterol with the antimuscarinic glycopyrronium [QVA149], based on the demonstration of positive effects on both lung function and PROs, is likely to be a further option for patients with severe COPD.
Graphical Abstract:
Keywords:
Adherence, bronchodilators, chronic obstructive pulmonary disease, efficacy, indacaterol, long-acting beta2- agonists, safety.
Affiliation:
Pulmonary Rehabilitation Unit, ICP Hospital, Via Bignami 1, Milan, Italy.