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Current Molecular Medicine
ISSN (Print): 1566-5240
ISSN (Online): 1875-5666
VOLUME: 14
ISSUE: 5
DOI: 10.2174/1566524014666140603101113









The Characteristics of Bax Inhibitor-1 and its Related Diseases

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Author(s): B. Li, R.K. Yadav, G.S. Jeong, H.-R. Kim and H.-J. Chae
Pages 603-615 (13)
Abstract:
Bax inhibitor-1 (BI-1) is an evolutionarily-conserved endoplasmic reticulum protein. The expression of BI-1 in mammalian cells suppresses apoptosis induced by Bax, a pro-apoptotic member of the Bcl-2 family. BI-1 has been shown to be associated with calcium (Ca2+) levels, reactive oxygen species (ROS) production, cytosolic acidification, and autophagy as well as endoplasmic reticulum stress signaling pathways. According to both in vitro and clinical studies, BI-1 promotes the characteristics of cancers. In other diseases, BI-1 has also been shown to regulate insulin resistance, adipocyte differentiation, hepatic dysfunction and depression. However, the roles of BI-1 in these disease conditions are not fully consistent among studies. Until now, the molecular mechanisms of BI-1 have not directly explained with regard to how these conditions can be regulated. Therefore, this review investigates the physiological role of BI-1 through molecular mechanism studies and its application in various diseases.
Keywords:
Bax inhibitor-1, ER stress, lysosome, reactive oxygen species, unfolded protein response.
Affiliation:
(H.-R. Kim) Department of Dental Pharmacology, School of Dentistry, Wonkwang University, Iksan, 570-749, Republic of Korea.